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Testosterone was often referred to as the "male" hormone, because it is responsible for developing some of the male characteristics such as lowering of the voice and hair growth, and because the male body produces much more of it than the female.
Testosterone in the male is produced mainly in the testis, a small amount being produced in the adrenal. It is synthesized from cholesterol. The regulation of its production may be simplified thus: the hypothalamus (part of the brain) produces gonadotrophin releasing hormone (GnRH) which acts on the anterior pituitary to increase the production of luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH acts on the Leydig cells in the testis, causing them to produce testosterone. FSH, together with testosterone act on the Sertoli cells in the testis to regulate the production and maturation of spermatozoa. Testosterone in turn acts on the hypothalamus and anterior pituitary to suppress the production of GnRH, FSHand LH, producing a negative-feedback mechanism which keeps everything well-regulated. The small amount produced in the adrenal (in both sexes) is regulated by secretion of adrenal corticotrophin hormone (ACTH), also secreted by the pituitary.
Testosterone, and its metabolites such as dihydrotestosterone, act in many parts of the body, producing the secondary sexual characteristics often male: balding, facial and body hair, deep voice, greater muscle bulk, thicker skin, and genital maturity. At puberty it produces acne, the growth spurt and the enlargement of the penis and testes as well as causing the fusion of the epiphyses (through its conversion to estrogens), bringing growth in height to an end. It plays some role in maintaining the sexual organs in the adult, but only a low concentration is required for this.
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