Metabolomics.co.uk
Title
HUSERMET Project Portal
Description
Metabolomics in Health
Many arguments, including those based on Metabolic Control Analysis (MCA), indicate that the metabolome should be a particularly high-resolution method for amplifying and thereby reflecting changes in the levels of gene products, especially those which accompany disease pathogenesis. A key imperative is therefore to establish the disease-independent ranges of the many hundreds of metabolites, which comprise the metabolome, to recognise the disease-independent changes that occur 'simply' as a function of diet, gender, age, therapeutic interventions and lifestyle.
Several thousand "normal", healthy volunteers are to be recruited with associated demographic data to allow effective data mining and definition of the normal ranges of metabolites within the population. The research cohort will cross age, gender, class and ethnic boundaries to give a comprehensive overview of the variability of the metabolome in the general population.
Such data will form the reference baseline that will allow prognostic and diagnostic biomarkers for disease progression to be identified reliably.
Languages
English
