BioAlly.com
BioAlly - In a friendly alliance with your stomach
Digestive tract consists of the esophagus, stomach, duodenum (the first part of the intestines) and intestines, lined by mucous membrane to protect the surface stomach lining from the destructive effects of hydrochloric acid. Understanding the Digestive difficulties: Improper digestion can lead to regurgitation of bile acids and bile salts into the stomach. Such an occurrence adversely changes the composition and amount of mucous generated in the stomach. The condition where this protective 'shield' is broken or diminished is known as gastritis and can present in both acute and chronic pattern.
H. Pylori infections
It is estimated that about two thirds of the world population are infected by helicobacter pylori. Actual infection rates vary - the Western/Developed nations have rates around 25% and less developed nations have much higher rates of infections. In the United States, infection is primarily in the older generations (about 50% for those over the age of 60 compared with 20% under 40 years) and the poorest. This is largely attributed to higher hygiene standards and widespread use of antibiotics. However, antibiotic resistance is appearing in H. pylori. There are already metronidazole resistant strains present in the UK population. There is also evidence of a higher incidence of symptoms in people who eat spicy foods, apparently because of the effect these foods have on the stomach lining. When the protective lining is reduced from certain foods, H. pylori is better able to spiral into the stomach wall. This is one of the reasons that it was (and still is) commonly thought that spicy foods caused stomach ulcers. In actual fact, it is the H. pylori that causes the stomach ulcers, but the spicy foods creates the conditions for h. pylori to cause problems.
In the absence of any treatments, H. pylori infection apparently persists for life; our immune systems are not able to eradicate it.
A peptic ulcer is a sore on the lining of the stomach or duodenum, which is the beginning of the small intestine. Helicobacter pylori (H. pylori) are bacteria, responsible for the majority of peptic ulcers and others are caused by long-term use of nonsteroidal anti-inflammatory agents (NSAIDs), like aspirin and ibuprofen. H. pylori weaken the protective mucous coating of the stomach and duodenum, which allows acid to get through to the sensitive lining beneath. Both the acid and the bacteria irritate the lining and cause a sore, or ulcer.
Esophageal reflux, commonly known as 'heartburn,' is a condition in which stomach acid washes back into the esophagus and causes irritation of the tissues lining the esophagus.
Irritable Bowel Syndrome (IBS), also known as 'spastic colon' is one of the most common chronic health disorders in the world and affects up to 20% of the population. It is a dysfunction of the bowel and large intestine, causing lower abdominal pain, cramping, constipation and diarrhea.
Crohn's Disease - is one of the Inflammatory Bowel Diseases that causes inflammation in the digestive tract (usually the small intestine), resulting in chronic pain and diarrhea. There may also be rectal bleeding, weight loss and even fever. Common symptoms:
- General weight loss
- Pain or discomfort in abdomen
- Poor appetite
- Bloating and flatulence
- Belching
- Nausea and vomiting
Composition: Recognizing the need for a healthier and more effective approach, without the side effects of the prescription drugs, BioAlly is a capsule which is used every day for the digestive tract and as a preventative for flare ups of stomach and digestive disorders such as IBS, Crohn's Disease, Gastritis, Acid Reflux (GERD), Ulcerative Colitis and Diverticulosis. BioAlly safely and effectively acts to improve digestive health, reduce inflammation and reduce and prevent digestive disorders. Each capsule of BioAlly contains: Panchamrit parpati (ASS) 95 mg Kshar dvey (BPN) 50 mg Shankh bhasm (ASS) 50 mg Hingwashtak churn (ASS) 75 mg Extract Mulethi Glycyrrhiza glabra 40 mg Extract Sunthi Zingiber officinale 40 mg Extract Guduchi Tinospora cordifolia 40 mg Extract Haldi Curcuma longa 40 mg Extract Amla Emblica officinalis 40 mg Extract Shatavri Asparagus racemosus 30 mg
Panchamrit parpati: this is one of the best medicines available for indigestion of food. It cures indigestion, sprue, hepato and splenomegaly, erosion of stomach mucosa due to bile pigment & is also used in IBS (inflammatory bowel syndrome) and duodenal ulcer.
Kshar dvey :
- Sajjikashar: this alkali counteracts the situation of hyperacidity, acts as a carminative and digestive.
- Yavakshar: it is a powder consisting of ash obtained from yav bhasm. This contains 12-15 % sodium and 20-25 % potassium. Thereby maintaining the sodium potassium pump within the body. This is of excellent use in acidity, bloating of stomach and pain in abdomen.
Shankh bhasm is a very fine white powder obtained from shankh (conch) & it contains 38-40 % calcium ions, which counteract acidic reflux. This is of use in hyperacidity, hyper emesis and hepato and splenomegaly .
Hingwashtak churn: it is a mixture of 7 carminative herbs, which increase digestion and remove constipation . Mulethi (Glycyrrhiza glabra) relieves pain; discomfort and other symptoms cause by acrid matter in the stomach and remove the irritating effect of acid & also act as a mild laxative. (Ref: I.M.M. page no. 582) Animal studies suggest that licorice improves the quality and quantity of the gastric mucosa by increasing the number of gastric fundus glands and the number of mucus cells per gland. In addition, licorice increases mucosal blood flow and help to prolong the life span of intestinal cells. It is useful in functional dyspepsia , treatment of intestinal metaplasia, atypical hyperplasia of gastric mucosa , reflux oesophagitis , gastro-duodenal ulcer , and gastric mucosal damage by aspirin and bile acid and peptic ulcer or gastric cancer in H. pylori-infected individuals . A variety of actions have been attributed to each primary active ingredient in licorice: 1) Glycyrrhizin protects the gastric mucosa, possibly by modulating prostaglandin activity. A glycyrrhizin-containing extract of licorice increases plasma secretin and pancreatic bicarbonate output and decreases gastrin secretion. 2) Glycyrrhizin inhibits in vitro replication of Helicobacter pylori and a number of viruses, including vaccinia, herpes simplex, paramyxovirus, and vesicular stomatitis viruses. 3) Both glycyrrhizin and glycyrrhetic acid have anti-inflammatory properties. Possible mechanisms may relate to inhibition of corticosteroid metabolism, release of reactive oxygen species by neutrophils, or prostaglandin, phospholipase A2, or free radical activity. In addition to its own effects, glycyrrhizin enhances the anti-inflammatory action of cortisone. 4) Glycyrrhizin protects hepatic cells from such toxins as carbon tetrachloride and allyl formate, presumably by preventing oxidative damage. 5) At least half a dozen of the flavonoids also act as antioxidants .
MIC (mg/L) distribution of Extractum liquiritiae (EL), glycyrrhizic acid (GL), glycyrrhetinic acid (GA) and acetylated glycyrrhetinic acid monoglucuronide (aGAMG) for 29 H. pylori strains. The MIC values of EL were >1600 and 800 mg/L for 21 and one of H. pylori strains, respectively. For EL, the maximum concentration was 1600 mg/L for 22 of the 29 tested strains, for all other compounds it was 400 mg/L for all strains.
Sunthi (Zingiber officinale): Ginger is a grateful stimulant, carminative, and is often given in dyspepsia, flatulent colic & alcoholic gastritis. It is extremely valuable in dyspepsia, flatulence, colic, vomiting , spasm and other painful affection of stomach and unattended bowel . Ginger is considered a tonic for the digestive tract, stimulating digestion and toning the intestinal muscles. This action eases the transport of substances through the digestive tract, lessens irritation of the intestinal walls & produces a pleasing sense of warmth. Ginger protects the stomach from the damaging effect of alcohol and non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen). In atonic conditions of the stomach and intestinal tract, it stimulates the structure to renewed activity and materially assists in the restoration of normal tone. It has a great ability to stop griping and cramping of the abdominal and intestinal area , exerts antiamoebicidal effect, reduces nausea , and symptoms of motion sickness. Ginger also reduces nausea due to anesthesia following surgery and because of chemotherapy . It has been found to have potential to help control H. pylori , , -associated gastro duodenal disease , . The combinations of propolis extract + clarithromycin and Z. officinale extract + clarithromycin exhibited improved inhibition of H. pylori with synergistic or additive activity on on clinical H. pylori isolates (n = 25), characterized in respect to both clarithromycin susceptibility and the presence of the cagA gene . Fractions of ginger (Zingiber officinale) extract also act as potent inhibitors of PPA and H. pylori growth.
Guduchi (Tinospora cordifolia), Glycyrrhiza glabra, & Emblica officinalis exhibit anti-ulcer and anti-oxidant activity, on gastric secretion and gastric ulcers in pylorus-ligation and ethanol-induced gastric mucosal injury in rats. The reduction in ulcer index, volume and total acidity, and an increase in the pH of gastric fluid in pylorus-ligated rats prove their anti-ulcer activity. The increase in the levels of superoxide dismutase, catalase, reduced glutathione and membrane bound enzymes like Ca2+ ATPase, Mg2+ ATPase and Na+ K+ ATPase and decrease in lipid proves the anti-oxidant activity of the formulation Guduchi fortifies the cellular immune functions to increase resistance against bacterial abdominal sepsis and E.coli induced peritonitis
Curcumin, one of the active ingredients in turmeric (Haldi-Curcuma longa), induces flow of bile, helps break down fats, reduces secretion of acid from the stomach and protects against injuries such as inflammation along the stomach (gastritis) or intestinal walls and ulcers from certain medications, stress, or alcohol and is also useful in dyspepsia. Turmeric extract not only increases the gastric wall mucus significantly but also restores the non-protein sulfhydryl (NP-SH) content in the glandular stomachs of the rats. Curcumin inhibits NF-kappaB activation and cell scattering, and acts as a potential therapeutic agent effective against pathogenic processes initiated by H. pylori infection . Curcumin shows a significant reduction in the degree of neutrophil infiltration (measured as decrease in myeloperoxidase activity) and lipid peroxidation (measured as decrease in malondialdehyde activity) in 2,4,6- trinitrobenzene sulphonic acid-induced colitis as well as decreased serine protease activity. Curcumin reduces the levels of nitric oxide (NO) and O2- associated with the favorable expression of Th1 and Th2 cytokines and inducible NO synthase, exerting beneficial effects on colitis and IBD (Inflammatory Bowel Disease.) C. longa ethanol extract and ethylacetate extract block the binding of [3H]-tiotidine to membrane receptors on HL-60 cells and inhibits gastric acid secretion by blocking H2 histamine receptors in a competitive manner . Intraduodenal administration of curcumin also markedly prevents the formation of acute mixed reflux esophagitis, together with reducing the incidence or the severity of neutrophil infiltration
Amla (Emblica officinalis) is useful in ulcer and non ulcer dyspepsia, gastritis, hyperacidity, constipation, colic, colitis & hemorrhoids. Fruit of Emblica officinalis possesses anti-pyretic and analgesic activity . It offers protection against ethanol-depleted stomach wall mucosa and reduces nonprotein sulfhydryl concentration. It exhibits antisecretory, antiulcer , and cytoprotective properties. It significantly reduces stress-induced leakage in gastric tissue and confers protection against ulcers . It is found to protect against pancreatitis induced by cerulein and also intraductal administration of bile, blood and trypsin. The major mechanism of action of amla is concluded through prostaglandin release and antioxidative action .
Shatavri (Asparagus racemosus): Well-established pharmacological properties of Asparagus racemosus include immunostimulation, anticancer, antiulcer , and antimicrobial etc. Asparagus racemosus (AR), belonging to the family Liliaceae, is a well-known ayurvedic rasayana. AR is reported to be antidiarrhoeal, antibacterial, antilithiatic and antiulcer. A series of experiments to evaluate the mechanisms of adaptogenic activity of Asparagus racemosus using various stress and immunostimulatory models are reported. The extract of Asparagus racemosus provides significant protection against stress-induced gastric mucosal damage , & acute gastric ulcers induced by pyloric ligation. It also increases the mucosal defensive factors like mucus secretion , cellular mucus , life span of cells, exhibits significant anti-oxidant effect , reduces volume of gastric acid secretion and ulcer index . Sairam et al ., have reported antiulcerogenic activity of methanolic extract of fresh roots of AR in the cold restraint (CRU), alcohol (AL), aspirin (ASP), and pyloric ligation (PL) induced gastric ulcer models and cysteamine induced duodenal ulcer model. AR was found to be effective in the CRU, AL, and cysteamine induced ulcer models, but was ineffective in PL and ASP models. The plant did not show any significant effect on acid and peptic activity, but it increased mucin secretion tremendously, suggesting cytoprotective property as the possible mechanism. The plant did not show any effect on acid secretion. However, its effect in the CRU model, apart from its effect on defensive mucosal factors, was attributed to its adaptogenic activity, This defensive system showed protection in the PL induced model. In the ASP model, both local and systemic effects produced ulcers . The ethanol and aqueous extract of Asparagus racemosus exhibited significant anti-diarrhoeal activity against castor oil induced diarrhoea in rats. The extracts had a similar activity as loperamide, when tested at 200 and 250 mg/kg and statistically significant reduction in the frequency of defecation and the wetness of the faecal droppings when compared to untreated control rats . Asparagus racemosus (Shatavari) is used in Ayurveda for dyspepsia (amlapitta) and as a galactogogue. It was hence compared with a modern drug, metoclopramide, which is used in dyspepsia to reduce gastric emptying time . Salient features:
• BioAlly is useful in treatment of atypical hyperplasia of gastric mucosa, reflux oesophagitis, gastro-duodenal ulcer, and gastric mucosal damage by aspirin, alcohol, NSAIDs and bile acid • BioAlly is useful in treatment of peptic ulcer or gastric cancer in H. pylori-infected individuals • BioAlly is useful in functional dyspepsia • BioAlly prevents the flare ups of IBS, Crohn's Disease, Gastritis, Acid Reflux (GERD), Ulcerative Colitis and Diverticulosis. • BioAlly tones the entire digestive system, soothe the stomach lining and maintain healthy digestive and bowel functioning. • BioAlly reduces the incidence of cramping, bloating, gas, acid reflux and other symptoms of digestive problems. • BioAlly fights against harmful free radicals in our body. • BioAlly removes nausea and other symptoms of digestive problems. • BioAlly stops symptoms of indigestion, heartburn and acid reflux
Strength Of BioAlly
1. A NEW PRESCRIPTION Whereas the existing antacids are targeting neutralization of gastric acid . BioAlly works by • Reducing the amount of acid your stomach produces • Inhibits gastric acid secretion by blocking H2 histamine receptor • Increase cellular immune response to infection • Accelerate process of healing ulcers • Inhibits proton pump i.e Inactivates H+/ K+ ATpase
2. RAPID AND SUSTAINING EFFECT BioAlly • Increases the mucosal defensive factors like mucus secretion, cellular mucus and life span of cell • Suppresses release of gastrin • Improve the pain accompanied with therapy for peptic ulcer.
3. REDUCED DOSAGE AND DURATION TIME OF ANTACIDS
4. MEDICATION FOR THE RELIEF OF HEARTBURN DURING PREGNANCY In addition to above BioAlly is also effective in hyperemesis symptoms. No adverse reactions have been reported.
Dosage:
Peptic ulcers and gastritis:
2 capsules thrice a day, before meals, along with water for a period of 15 days.
Reduce the dose to 1 capsule thrice a day for next 15 days as maintenance.
Regurgitation, heartburn, nausea, vomiting, and dyspepsia: one capsules a day or as and when required with water.
Side effects: not reported so far
Presentation: blister pack of 10 capsules
for more information- contact Dr Charminder Kaur, BF-103, Janakpuri, New Delhi-110058, India or call at +91-011-9899547770
