KapsForKendall.com
Title
Fanconi Anemia Chemo Cap Project
Description
Fanconi Anemia (FA), named for Swiss pediatrician, Guido Fanconi, is one of the inherited anemia's that leads to bone marrow failure (aplastic anemia). It is a recessive disorder: if both parents carry a defect (mutation) in the same FA gene, each of their children has a 25% chance of inheriting the defective gene from both parents. When this happens, the child will have FA.
There are at least seven FA genes: A, C, D2, E, F, G and BRCA2 (as announced in the article entitled Biallelic Inactivation of BRCA2 in Fanconi Anemia in the July 26, 2002 edition of Science). Six of these genes have been cloned. These six account for more than 85% of the cases of Fanconi anemia. Mutations in FA-A and FA-C account for FA in 76% of patients worldwide.
FA occurs equally in males and females. It is found in all ethnic groups. Though considered primarily a blood disease, it may affect all systems of the body. Many patients eventually develop acute myelogenous leukemia (AML). Older patients are extremely likely to develop head and neck, esophogeal, gastrointestinal, vulvar and anal cancers. Patients who have had a successful bone marrow transplant and, thus, are cured of the blood problem associated with FA still must have regular examinations to watch for signs of cancer. Many patients do not reach adulthood.
Contact
- Jeanne Atkinson
-
- Centennial Colorado
- United States 80112
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- 3037415854
