ActIvBiotics.com

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ActivBiotics

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We are a biopharmaceutical company focused on the discovery, development and commercialization of therapies for the treatment of inflammatory diseases and bacterial infections. Our lead product candidate, rifalazil, is a proprietary, orally administered antibacterial agent, which is in a Phase III clinical trial for the treatment of intermittent claudication associated with peripheral arterial disease, or PAD. PAD is a result of atherosclerosis of the arteries located in the lower extremities. Intermittent claudication is pain, cramping or fatigue in the lower extremities brought on by exertion or walking and is the most common symptom of PAD. We have also initiated a separate Phase II clinical trial of rifalazil, called RESTORE-IT, for the treatment of atherosclerosis of the carotid arteries, which are the major arteries of the head and neck. Our second product candidate, M40403, is a proprietary synthetic small molecule that is designed to mimic the function of a naturally occurring enzyme that plays a role in several inflammatory disease states. We plan to initiate one or more Phase II clinical trials of M40403. In addition to our clinical programs, we continue research efforts focused on identifying product candidates for the treatment of inflammatory diseases and bacterial infections from our proprietary antibacterial and anti-inflammatory libraries. We currently hold worldwide commercial rights to all of our product candidates.