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- Disorders like depression may be caused by an imbalance of chemical messengers in the brain. (6) One of these chemical messengers is serotonin. Serotonin helps send electrical signals from one nerve cell to another. In the process, serotonin is released from one nerve cell (the sender) and travels to the next (the receiver), where it is either absorbed or returns back to the original sender cell. When a person suffers from depression, there may be a problem with the balance of the serotonin system that affects the cell to cell communication.